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A trifunctional reagent for photoaffinity labeling

✍ Scribed by Thomas Rühl; Lothar Hennig; Yasumaru Hatanaka; Klaus Burger; Peter Welzel

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
141 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A photolabel, a biotin tag, and a moenomycin ligand have been attached orthogonally to the three functional groups of isoserine to provide compound 13 that is to be used in anity labeling of penicillin binding protein 1b. The urethane group in 13 can be cleaved with n-butylamine in methanol or water.

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