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A trial of flunarizine in the treatment of duchenne muscular dystrophy

✍ Scribed by Dr. David J. Dick; David Gardner-medwin; Peter G. Gates; Mary Gibson; Judy M. Simpson; Timothy J. Walls

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
491 KB
Volume
9
Category
Article
ISSN
0148-639X

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty-seven boys with Duchenne muscular dystrophy (DMD) entered a double-blind controlled trial of treatment with the calcium antagonist flunarizine. They were matched for age and disability. At monthly intervals, muscle power, functional ability, locomotor score, contractures, and forced vital capacity were measured by a team not involved in clinical care. Over a period of 1 year, flunarizine in a dose of up to 0.25 mglkglday had no effect on the clinical course of the disease.

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