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A Transition State for the Enantioselective Deprotonation of N-Boc-Pyrrolidine with Isopropyllithium/(−)-Sparteine

✍ Scribed by Kenneth B. Wiberg; William F. Bailey

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
186 KB
Volume
112
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES

Chiral diamines. Part 3: Effect of ligan
Chiral diamines. Part 3: Effect of ligand structure on the enantioselective deprotonation of N-Boc-pyrrolidine with i-PrLi: a computational comparison of (−)-sparteine and (S,S)-1,2-bis(N,N-dimethylamino)cyclohexane
✍ Kenneth B. Wiberg; William F. Bailey 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 320 KB

The deprotonation N-Boc-pyrrolidine by i-PrLi-(S,S)-1,2-bis(N,N-dimethylamino)cyclohexane has been studied at the HF/3-21G and B3P86/6-31G\* theoretical levels. The two lowest energy complexes of the N-Boc-pyrrolidine-i-PrLi-diamine ligand, as well as the transition states leading to proton transfer