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A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms

โœ Scribed by RF Souza; J Lei; J Yin; R Appel; TT Zou; X Zhou; S Wang; MG Rhyu; K Cymes; O Chan; WS Park; MJ Krasna; BD Greenwald; J Cottrell; JM Abraham; L Simms; B Leggett; J Young; N Harpaz; SJ Meltzer


Book ID
118519898
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
280 KB
Volume
112
Category
Article
ISSN
0016-5085

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Alteration of transforming growth factor beta1 (TGF-beta1) type II receptor (RII) appears to cause unresponsiveness to TGF-beta1 in tumorigenic cells. Defect in the mononucleotide repeat sequence, i.e., poly A region of TGF-beta1RII gene has been reported to be related to replication error-positive