A toxic substance produced byNocardia otitidiscaviarumisolated from cutaneous nocardiosis

✍ Scribed by Yuzuru Mikami; Sen Feng Yu; Katsukiyo Yazawa; Kazutaka Fukushima; Akio Maeda; Jun Uno; Kiyoshi Terao; Naoki Saito; Akinori Kubo; Ken -ichiro Suzuki

• Publisher: Springer Netherlands
• Year: 1990
• Tongue: English
• Weight: 439 KB
• Volume: 112
• Category: Article
• ISSN: 0301-486X
• DOI: 10.1007/bf00436506

✦ Synopsis

During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LDso value was 1.25 mg/kg and the EDso value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68012. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.