A Total Synthesis of (±)- Aphidicolin: Regio- and stereoselective conversion of 3α,18-Di-O-benzyl-17-nor-14-aphidicolen-16-one into (±)-aphidicolin

A Total Synthesis of Aphidicolin: Stereo

A Total Synthesis of Aphidicolin: Stereospecific Synthesis of (±)-3α, 18-Dihydoxy-17-Noraphidicolan-16-one

✍ Rinaldo Marini Bettolo; Pietro Tagliatesta; Alessandro Lupi; Doriano Bravetti 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 German ⚖ 423 KB

## Abstract A simple, efficient, and stereospecific total synthesis of (±)‐3α, 18‐dihydroxy‐17‐noraphidicolan‐16‐one **(2)**, by solvolytic rearrangement of the __endo__‐bicyclo‐[2.2.2]oct‐5‐en‐2‐yl methanesulfonate **16**, is described. Since aphidicolin **(1)** has already been obtained from **2*