𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A total synthesis of (±)-1-desoxyhypnophilin: using ring closing metathesis for the construction of cyclic enones

✍ Scribed by David C Harrowven; Matthew C Lucas; Peter D Howes

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
73 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The paper describes the first total synthesis of (±)-1-desoxyhypnophilin, a linear triquinane isolated from the East African mushroom Lentinus crinitus which displays promising antimicrobial activity. The key strategic feature is a new cyclopentannulation method for appending cycloalkenones onto ketones involving sequential use of a ring closing metathesis reaction with a tertiary allylic alcohol and a PCC induced oxidative rearrangement.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Total Synthesis o
ChemInform Abstract: A Total Synthesis of (.+-.)-1-Desoxyhypnophilin: Using Ring Closing Metathesis for the Construction of Cyclic Enones.
✍ David C. Harrowven; Matthew C. Lucas; Peter D. Howes 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v