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A Thymidine Phosphorylase-Stable Analogue of BVDU with Significant Antiviral Activity

✍ Scribed by Guenther, Sven; Balzarini, Jan; De Clercq, Erik; Nair, Vasu


Book ID
125525569
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
231 KB
Volume
45
Category
Article
ISSN
0022-2623

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Synthesis of neplanocin A, a potent antiviral carbocyclic nucleoside, from adenosine was achieved. An acyclic adeninenucleoside 21, prepared from adenosine, was converted to 4'-keto acyclic derivative 27. When 27 was treated with lithiotrimethylsilyldiazomethane in THF, a C-H insertion reaction at t