Protease pro region required for folding
✍
David Baker; Joy L. Silen; Dr. David A. Agard
📂
Article
📅
1992
🏛
John Wiley and Sons
🌐
English
⚖ 582 KB
## Abstract α‐Lytic protease, an extracellular bacterial serine protease, is synthesized with a large pro region that is required in vivo for the proper folding of the protease domain. To allow detailed mechanistic study, we have reconstituted pro region‐dependent folding in vitro. The pro region p