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A Thermostable Aldolase for the Synthesis of 3-Deoxy-2-ulosonic Acids

✍ Scribed by Henry J. Lamble; Sylvain F. Royer; David W. Hough; Michael J. Danson; Garry L. Taylor; Steven D. Bull

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 87 KB
Volume: 349
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200600520

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✦ Synopsis

Abstract

A stereochemically promiscuous 2‐keto‐3‐deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C~3~‐ and C~4~‐aldoses to afford syn‐ and anti‐3‐deoxy‐2‐ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C~6~‐ and C~7~‐3‐deoxyhept‐2‐ulosonic acids to be produced in an efficient manner.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v