A Thermosensitive and Biodegradable Physical Gel with Chemically Crosslinked Nanogels as the Building Block
✍ Scribed by Zigang Yang; Jiandong Ding
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 238 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
A triblock copolymer, poly(ethylene glycol)–poly(propylene glycol)–poly(ethylene glycol) was end‐capped by acryloyl groups using a biodegradable oligolactide as spacer, and such biodegradable amphiphilic macromers could form micelles in water. A nanogel was prepared via polymerizing macromers in a micelle, and a macroscopic physical gelation was found upon heating a concentrated aqueous nanogel suspension. Such a sol–gel transition with a chemically crosslinked nanogel as the building block was thermoreversible. While the hydrogel affords a promising injectable biomaterial; this research reveals new physics of the thermogelling mechanism of amphiphilic block copolymers.
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