✦ LIBER ✦
A Thermoresponsive Hydrogel Based on Telechelic PEG End-Capped with Hydrophobic Dipeptides
✍ Scribed by Ian W. Hamley; Ge Cheng; Valeria Castelletto
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 561 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The self‐assembly in aqueous solution of PEG (1 500 Da) telechelically end‐capped with hydrophobic dipeptides has been investigated using spectroscopic, microscopic, scattering, and rheological methods. A self‐assembled β‐sheet fibril‐based hydrogel has been identified (containing dityrosine end groups), which exhibits a gel–sol transition near body temperature. This thermo‐responsive PEG‐based biofunctional hydrogel is expected to have diverse potential uses in delivery or diagnostics for biomedical applications. magnified image