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A Thermolabile Variant of Methylenetetrahydrofolate Reductase Is a Determinant of Hyperhomocyst(e)inemia in the Elderly

✍ Scribed by Jun-Hyun Yoo


Book ID
111397126
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
121 KB
Volume
928
Category
Article
ISSN
0890-6564

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A common haplotype for the 677T thermola
✍ M. Linnebank; A. Homberger; U. Nowak-GΓΆttl; H. G. Koch πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 18 KB

The common polymorphic transition 677C>T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene causes a thermolabile enzyme variant. This variant is associated with moderate hyperhomocysteinemia, a risk factor for vascular disease and thrombophilia. Up to now, it remained unclear if the therm