A thermal analysis study of ascorbic acid and its pharmaceutical formulations
β Scribed by S. Lerdkanchanaporn; D. Dollimore; K. S. Alexander
- Publisher
- Springer Netherlands
- Year
- 1997
- Tongue
- English
- Weight
- 442 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-5215
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π SIMILAR VOLUMES
## Abstract A rapid, sensitive and stability indicating high performance liquid chromatographic method was developed and validated for the analysis of dehydroepiandrosterone (DHEA) in pharmaceutical tablet formulation. The analysis was done on a Supelcosil C~18~ column (25 cm Γ 4.6 mm i.d., 5 Β΅m).
The STOSG optimized structures of nine different staggered conformers of ascorbic acid are presented. The largest energy difference between the nine local minima is 5.1 kcal/mol. Comparison of the relative energies of the fully optimized structures of ascorbic acid conformers with those of nonoptimi