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A Theory of the Mechanism of Action of Creatine Phosphokinase

✍ Scribed by RABIN, B. R.; WATTS, D. C.


Book ID
109611382
Publisher
Nature Publishing Group
Year
1960
Tongue
English
Weight
279 KB
Volume
188
Category
Article
ISSN
0028-0836

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Beta amyloid peptides (AP), etiologically associated with Alzheimer's disease (AD), have been shown to inhibit both glutamine synthetase (GS) and creatine phosphokinase (CPK) in vitro. These two enzymes are affected in AD and are sensitive to oxidative stress. Residue 35 of the AP25-35, the most pot