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A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system

✍ Scribed by Harel Weinstein; Shalom Srebrenik; Saul Maayani; Mordechai Sokolovsky


Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
748 KB
Volume
64
Category
Article
ISSN
0022-5193

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We used a novel pharmacokinetic-pharmacodynamic (PK-PD) approach that had been applied for signal transduction kinetics to investigate the kinetics of the parasympathomimetic effect of scopolamine and atropine in rats. The parasympathetic tone was assessed by continuous measurement of the power of t