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A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation

โœ Scribed by Brian D Kavanagh; Timothy W Secomb; Richard Hsu; Peck-Sun Lin; Jurgen Venitz; Mark W Dewhirst


Book ID
108434746
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
171 KB
Volume
53
Category
Article
ISSN
0360-3016

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## Abstract When oxygen binds to one of the subunits of hemoglobin, the oxygen affinity of the other subunits is enhanced. This cooperative interaction of the subunits is initiated by the movement of the heme plane toward the proximal side when oxygen binds to the heme. This motion is transmitted t