A mammalian cell line designed to test t
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Lewis I. Pizer; Dawn H. Mitchell; Beatrice Bentele; Joan L. Betz
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Article
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1987
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John Wiley and Sons
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French
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The herpes simplex virus (HSV) thymidine kinase (tk) gene was transfected into Chinese hamster ovary (CHO) 51-1 I glycells to test its effect on the cytotoxic and mutagenic activity of anti-herpetic nucleoside analogues. Insertion of the viral tk was verified by Southern blot analysis, by sensitivit