𝔖 Bobbio Scriptorium
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A testing strategy to evaluate the mutagenic activity of industrial chemicals in cultured mammalian cells

✍ Scribed by Li, A.P.


Book ID
122756463
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
360 KB
Volume
5
Category
Article
ISSN
0273-2300

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The herpes simplex virus (HSV) thymidine kinase (tk) gene was transfected into Chinese hamster ovary (CHO) 51-1 I glycells to test its effect on the cytotoxic and mutagenic activity of anti-herpetic nucleoside analogues. Insertion of the viral tk was verified by Southern blot analysis, by sensitivit