A test for linkage and association in general pedigrees
โ Scribed by Norman L. Kaplan; Stephanie A. Monks; Eden R. Martin
- Book ID
- 114432561
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 175 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1466-920X
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๐ SIMILAR VOLUMES
There are numerous statistical methods for quantitative trait linkage analysis in human studies. An ideal such method would have high power to detect genetic loci contributing to the trait, would be robust to non-normality in the phenotype distribution, would be appropriate for general pedigrees, wo
## Abstract Many complex human diseases such as alcoholism and cancer are rated on ordinal scales. Wellโdeveloped statistical methods for the genetic mapping of quantitative traits may not be appropriate for ordinal traits. We propose a class of varianceโcomponent models for the joint linkage and a
## Abstract Many familyโbased tests of linkage disequilibrium (LD) are based on counts of alleles rather than genotypes. However, alleleโbased tests may not detect interactions among alleles at a single locus that are apparent when examining associations with genotypes. Familyโbased tests of LD bas
## Abstract Lately, many different methods of linkage, association or joint analysis for family data have been invented and refined. Common to most of those is that they require a map of markers that are in linkage equilibrium. However, at the present day, highโdensity single nucleotide polymorphis