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✦   LIBER   ✦

A technique for the automated analysis of cardiac muscle function

✍ Scribed by Richard A. McPherson; John F. Lavelle; William F. Friedman; James W. Covell

Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
883 KB
Volume
5
Category
Article
ISSN
0010-4809

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✦ Synopsis

The mechanical performance of isolated cardiac muscle usually has been examined with a simple lever system for the analysis of the effects of alterations in muscle length and loading on cardiac muscle function. The system described in this report utilizes a hybrid computer and closed-loop servo system to control muscle length and load. Muscle length is monitored by a photo-diode and tension by a strain gauge transducer. These signals are amplified, scaled and transmitted to an analog computer. Error signals are determined for control of muscle length or tension for isotonic and isometric modes of contraction. The error signal and a power amplifier provides a current through wire wound about a pendulum positioned in a magnetic field perpendicular to the current direction. A horizontally oriented papillary muscle is attached to the base of the pendulum. The major strengths of the current system are its versatility and the ease with which changes in experimental protocol and data retrieval can be carried out.

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