Automatic counting of chromosomes by computer is a feasible technique for screening human populations for aneuploidy. This paper presents a system which has been developed around a new lithium-treated chromosome preparation. 35 mm negatives of metaphase chromosome spreads are scanned fully automatic
A technique for counting numerous chromosomes
β Scribed by Tze-Tuan Chen
- Publisher
- John Wiley and Sons
- Year
- 1946
- Tongue
- English
- Weight
- 224 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0362-2525
No coin nor oath required. For personal study only.
β¦ Synopsis
Aiigclcs
ELEVEN FIGURES
F o r some years the writer has been studying ('lironiosomes iii Paramecium, especially those in P. bursaria. There were found in this species many polyploid races, each having nu- iiiei*ous chromosomes running up to several 11undred.l I n order to ascertain the number of chromosomes in each race, a method of counting them was devised. The writer believes this method might also be useful in studying other organisms having iiumerous chromosomes. The method consists essentially of the use of a special ocular disc in drawing chromosomes, with the drawings made on celluloid sheets.'
The ocular disc is made of optical glass, in the center of wliicli is a square ruled into a number of divisions. Ocular disc type I will be used as a n example. The 3-inn1 square is
π SIMILAR VOLUMES
Responding to Leimkuhler's call for more computer experimentation in informetrics, this numerical study aims to illustrate observed appearances of fractional counts graphs. For instance, assuming a Lotka distribution for articles per author, it shows that for fields in which the singleauthor article