## Abstract Accurate quantification of NMR metabolites by spectral modeling requires assumed lineshape functions. For singlet resonances, a combination of Lorentzian and Gaussian lineshapes is sufficient, but for weakly Jβcoupled resonances such as lactate, more complex lineshapes are necessary. In
A systematic study of the lactate lineshape in PRESS-localized proton spectroscopy
β Scribed by Ian Marshall; James Wild
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 668 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Jβcoupled resonances such as lactate exhibit complex behavior in PRESSβlocalized spectroscopy. Polarization transfer effects due to nonideal slice profiles can lead to substantial errors in quantification unless recognized. In this work, it is shown how these effects can be predicted in a systematic way given the sequence timing and the RF pulse envelopes. Experimental results are presented to highlight the problems of working at the popular echo time of 2/J.
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