A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer

Loss of MKK4 expression in ovarian cance

Loss of MKK4 expression in ovarian cancer: A potential role for the epithelial to mesenchymal transition

✍ Shamima Yeasmin; Kentaro Nakayama; Mohammed Tanjimur Rahman; Munmun Rahman; Masa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 697 KB

## Abstract In the current study, we investigated the mechanism relating downregulation of mitogen‐activated protein kinase kinase 4 (MKK4) expression to development of ovarian cancer. Over‐expression of the MKK4 gene in TOV‐21 G cells, a line with homozygous deletion of MKK4, resulted in morpholog