A synthetic approach towards the aromatic macrocyclic core of diazonamide A based on sp2-sp2 coupling protocols

✍ Scribed by Alicia Boto; Matthew Ling; Graham Meek; Gerald Pattenden

• Book ID: 104260071
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 217 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01819-x

✦ Synopsis

The scope for a range of sp2-sp 2 coupling protocols to elaborate the phenyl-indole, indoleoxazole, oxazole-oxazole, and quaternary carbon units in the marine natural product diazonamide A 1 are described, leading to the synthesis of the benzofuran oxazoles lla and 18, the benzofuran/biphenyl/indole 16, and the indole-bis-oxazole 25.