A synthetic approach to polyene macrolldes: Synthesis of the building blocks
β Scribed by Barry M. Trost; Peter Metz; Jeffrey T. Hane
- Book ID
- 104219380
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 208 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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Synthetic applications of isocyanldes have become widespread In recent years.' In this conmunlcatlon we wish to report on the synthesis of tosylmethyllsocyanlde (To&IX) (Ia) and related compounds. The succeeding papers2 deal with the unique synthetic applications of Ia
Phosphonodifluorodithioacetate 2 demonstrates high reactivity towards dienes due to the presence of the two fluorine atoms. A hetero Diels-Alder reaction afforded the corresponding dihydrothiapyrans in 60-90% yields. These adducts can be submitted to a selective dihydroxylation and desulfanylation t