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A synthesis of γ-lactones by reaction of lithium β-lithiopropionate with aldehydes and ketones

✍ Scribed by Drury Caine; A.Stephen Frobese

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
199 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

Several synthons of b-carboxy carbanions (2) have been added to aldehydes and/or ketones the products ultimately converted into y-butyrolactones Q).l However, this methodology normally requires the use of system. We wish to report a B-lithiopropionate (2) to an adduct. complex reagents and/or several steps to elaborate the butanolide direct synthesis of y-lactones which involves the addition of lithium aldehyde or ketone followed by lactonization of the y-hydroxy acid --COH 2

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