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A Synthesis of the Potent A 2 Selective Adenosine Agonist N 6 -[2-(3,5-Dimethoxyphenyl)-2-(2-Methylphenyl)Ethyl]Adenosine, and Its 5′-N-Ethyl Ribofuranuronamide Derivative

✍ Scribed by Bridges, Alexander J.


Book ID
121465135
Publisher
Taylor and Francis Group
Year
1989
Tongue
English
Weight
592 KB
Volume
8
Category
Article
ISSN
0732-8311

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We recently reported that 2-substitution of M-benzyladenosine-5'-uronamides greatly enhances selectivity of agonists for rat A, adenosine receptors (J. Med. Chem. 1994, 37, 3614-3621). Specifically, 2-Chloro-M-(3-iodobenzyl)adenosine-5'-Nmethyluronamide (2-CI-IB-MECA), which displayed a K, value of