A Synthesis of Enantiomerically Pure 3- and 3,3-Disubstituted Pyrrolidines
β Scribed by Larry J. Westrum; A.I. Meyers
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 275 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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Conjugate addition-rearrangement of N-substituted hydroxylamines sugar &lactones provides a short and effective route to title compounds. to cr,8-unsaturated Despite the interesting heterocyclic skeleton of isoxazolidin-5-ones, having a potential synthetic and pharmacological value, there are only a
Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form. Some commentS and studies regarding pyrrolidine ring closure (key step) are also qorted. Over the last few years, interest in pyrrolidine-type derivatives has grown considerably, from b