A synthesis of alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates
✍ Scribed by Petra Štefanič; Matej Breznik; Nina Lah; Ivan Leban; Janez Plavec; Danijel Kikelj
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 87 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
A general synthesis of new alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate peptidomimetic building blocks from the corresponding alkyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates through carbanion oxidation is described.
## Abstract magnified image Substituted 4‐(5‐alkyl‐thiazol‐2‐ylmethyl)‐3,4‐dihydro‐2__H__‐1,4‐benzoxazines and 5‐(2,3‐dihydro‐1,4‐benzoxazin‐4‐ylmethyl)‐4‐methyl‐1‐phenyl‐1__H__‐pyrazol‐3‐ylamines were prepared by the reaction of (2,3‐dihydro‐1,4‐benzoxazin‐4‐yl)‐acetic acid methyl ester and some