A synovial sarcoma with a complex t(X; 18;5;4) and a break in the ornithine aminotransferase (OAT)LI cluster on Xp11.2
✍ Scribed by D. Olde Weghuis; B. De Leeuw; R. F. Suijkerbuijk; A. Geurts Van Kessel; M. E. J. Stoepker; E. Van Den Berg; B. De Jong; W. M. Molenaar
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 331 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
The initial cytogenetic analysis of a biphasic synovial sarcoma revealed complex anomalies involving six different chromosomes: 46,Y,t(X I85;4)(p I I ;q I I ;p I 3;q I2),t(2;5)(q35;q I I). After fluorescence in situ hybridization (FISH) analysis, using chromosome X-specific plasmid library and YAC probes, the situation appeared to be even more complex, with an insertion of part of the X chromosome short arm into the der(5)t(5; 18). In spite of these complex chromosomal rearrangements, the Xp I I breakpoint could be mapped to within the ornithine aminotransferase (0AT)LI cluster, very similar to that reported previously for the standard t(X I8)(p I I ;q I I ) in synovial sarcomas. These findings suggest common pathogenetic pathways in these cytogenetically different but morphologically similar tumors. Genes Chrom Cancer 9:288-291 ( I 994).