A summary of the papers in this month's issue

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 37 KB
• Volume: 1
• Category: Article
• ISSN: 1464-3383
• DOI: 10.1016/s1464-3383(04)80004-6

✦ Synopsis

The Tetrahedron journals carry a wide diversity of papers in combinatorial and solid-phase chemistry. This month Combinatorial Chemistry -An Online Journal includes several papers describing useful advances in library chemistry, both in solution and on resin support, as well as some useful library analysis methods and two examples of library applications.

Solid-phase library chemistry

In this month's issue, a new method for the synthesis of α-amino acids on solid-phase is described (Barbaste et al, Tetrahedron Letters, 1998, 39(35), 6287-6290). N-Acetyl dehydroalanines, bound to Wang resin through the Mitsunobu reaction have been derivatised by the Michael addition of nucleophiles including 1,2,4-triazole and pyrazole.