Detection of gene-environment interactions using an exhaustive search necessarily raises the multiple hypothesis problem. While frequently used to control for experiment-wise type I error, Bonferroni correction is overly conservative and results in reduced statistical power. We have previously shown
A sufficiently fast algorithm for finding close to optimal clique trees
✍ Scribed by Ann Becker; Dan Geiger
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 172 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0004-3702
No coin nor oath required. For personal study only.
✦ Synopsis
We offer an algorithm that finds a clique tree such that the size of the largest clique is at most (2α + 1)k where k is the size of the largest clique in a clique tree in which this size is minimized and α is the approximation ratio of an α-approximation algorithm for the 3-way vertex cut problem. When α = 4/3, our algorithm's complexity is O(2 4.67k n • poly(n)) and it errs by a factor of 3.67 where poly(n) is the running time of linear programming. This algorithm is extended to find clique trees in which the state space of the largest clique is bounded. When k = O(log n), our algorithm yields a polynomial inference algorithm for Bayesian networks.
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