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A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR

โœ Scribed by Wirawit Piyamongkol; Joyce C. Harper; Jon K. Sherlock; Alpesh Doshi; Paul F. Serhal; Joy D. A. Delhanty; Dagan Wells

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
252 KB
Volume
21
Category
Article
ISSN
0197-3851

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Preimplantation genetic diagnosis (PGD) allows the selection of unaffected IVF embryos for transfer in couples that are at risk for transmitting genetic diseases. For monogenic diseases, polymerase chain reaction (PCR)-based diagnosis is usually performed on single blastomeres. In Greece, up to 10 p