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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

✍ Scribed by Samsiddhi Bhattacharjee; Preetha Rajaraman; Kevin B. Jacobs; William A. Wheeler; Beatrice S. Melin; Patricia Hartge; Meredith Yeager; Charles C. Chung; Stephen J. Chanock; Nilanjan Chatterjee

Book ID: 113423218
Publisher: American Society of Human Genetics
Year: 2012
Tongue: English
Weight: 582 KB
Volume: 90
Category: Article
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2012.03.015

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On a general class of conditional tests

On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations

✍ Christoph Lange; Nan M. Laird 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB 👁 2 views

## Abstract Family‐based association tests (FBATs) provide simple and powerful tests to detect association between a genetic marker and a disease‐susceptibility locus, manifest in subjects by a phenotype or disease trait. Here we propose a new class of conditional tests for family‐based association