A study on the provocative day test effect of ivermectin and albendazole on nocturnal periodic Wuchereria bancrofti microfilaraemia

✍ Scribed by Samuel K. Dunyo; Francis K. Nkrumah; Paul E. Simonsen

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 440 KB
• Volume: 93
• Category: Article
• ISSN: 0035-9203
• DOI: 10.1016/s0035-9203(99)90066-4

✦ Synopsis

We conducted a randomized double-blind placebo-controlled study, in the Ahanta West District of Ghana, on the provocative day test effect of ivermectin and albendazole alone and in combination on nocturnal periodic Wuchereria bancroftimicrofilaraemia.

Sixty-three individuals with high night-time microfilaria (mf) intensities were identified in 1997 or 1998 and randomized into 4 groups. Blood samples for mf were then collected from the same individuals in the daytime (between 09:OO and 15:00) immediately before and 30-50 min after treatment. Groups l-4 were treated with ivermectin alone (150-200 pg/kg), albendazole alone (400 mg), the combination ofivermectin and albendazole, and placebo, respectively. Intensities ofmf in daytime samples were considerably lower than in night-time samples. Neither ivermectin or albendazole alone nor their combination provoked significant liberation of W. bancrofti mf into the peripheral circulation after the daytime treatment.