A study of theHLA-Dregion in patients with classic Kaposi's sarcoma

✍ Scribed by Elizabeth Robbins; Nadine Cohen; Licino Contu; Jean Dausset

• Book ID: 104746459
• Publisher: Springer-Verlag
• Year: 1986
• Tongue: English
• Weight: 257 KB
• Volume: 24
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00373118

✦ Synopsis

The HLA-D region in nine Sardinian patients with classic Kaposi's sarcoma was studied with two restriction enzymes, Eco RI and Eco RV, and two cDNA probes, DR/3 and DQ/3. A total of 41 polymorphic restriction fragments were identified. One, an 11.5 kb Eco RV DQ/3 fragment, was present in three of the patients but in none of the controls; a second, an 8.0 kb Eco RV DR/3 fragment, was present in six patients and all the controls. No single fragment was identified which was significantly over or underrepresented in either group.