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A study of the stability and radiochemical purity of some radiopharmaceuticals. 2. Labelled chlormerodrin

✍ Scribed by J. Buriánek; J. Cífka

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
748 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The chromatographic behaviour of chlormerodrin and its radiochemical impurities was studied in various solvents. The main product of thermal decomposition of chlormerodrin was identified as 3‐chloromercuri‐2‐hydroxypropylurea. The thermal decomposition of chlormerodrin is accelerated by the presence of theophylline and suppressed by sodium chloride. The main product of radiation decomposition of chlormerodrin is inorganic mercury. The yield of radiation decomposition was studied as a function of the concentration of chlormerodrin. The radiation decomposition of chlormerodrin is not essentially influenced by the presence of some other substances, however these substances can under certain circumstances support the formation of 3‐chloromercuri‐2‐hydroxypropylurea as the product of the radiolysis.

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