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A study of the antitumor activity of four dibutyltin(IV)-N-arylidene-α-amino acid complexes

✍ Scribed by Nwaka Ogwuru; Lian E. Khoo; George Eng

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
348 KB
Volume
12
Category
Article
ISSN
0268-2605

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✦ Synopsis

This paper reports the activity of four dibutyltin(IV)-N-arylidene-a-amino acid complexes against the National Cancer Institute (NCI) panel of 60 cell lines. The results indicated that three of the organotin complexes (C 17 H 25 NO 3 Sn, C 18 H 27 NO 3 Sn and C 20 H 31 NO 3 Sn) exhibit their highest cytotoxic effect on the NCI-522 (nonsmall cell lung cancer) cell line. The fourth complex, C 21 H 27 NO 3 Sn, exhibits its highest cytotoxic activity on the cell line RXF-631L (renal cancer). In general, a low to moderate cellular response was observed for all the organotin complexes, with at least one cell line in each subpanel of cells exhibiting a very low growth inhibition response to all the organotin complexes. The low-responding cell lines included HOP-62 (non-small lung cancer), DLD-1 (colon cancer), SF-539 (CNS cancer), SK-MEL-5 (melanoma), IGROV-1 (ovarian cancer) and RPMI-8226 (leukemia). The results also indicated that the compounds did not exhibit any significant subpanel activity and suggested that the compounds were not active in all the cell lines contained in any subpanel. The low to moderate activity of these compounds across the cell lines was attributed to the presence of nitrogen-bearing ligands which prevented the dissociation of the compound and the subsequent binding to DNA.

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