Activation of purinoceptor by ATP induces in eosinophils various cell responses including calcium transients, actin polymerization, production of reactive oxygen metabolites, CD11b-expression, and chemotaxis. Here, the effect of ion channel-gated P2X and/or G protein-coupled P2Y receptor agonists AT
A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors
β Scribed by Catherine Vial; Michael G Rolf; Martyn P Mahaut-Smith; Richard J Evans
- Book ID
- 110007076
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 418 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0007-1188
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## Abstract In the rat brain, a heteromeric association between adenosine A~1~ and purinergic P2Y~1~ receptors has been demonstrated. It is suggested that this association plays an important role in the control of purineβmediated responses during pathophysiological conditions. Recently, we have dem
## Abstract A physiological concentration of extracellular ATP stimulated biphasic Ca^2+^ signal, and the Ca^2+^ transient was decreased and the Ca^2+^ sustain was eliminated immediately after removal of ATP and Ca^2+^ in RBAβ2 astrocytes. Reintroduction of Ca^2+^ induced Ca^2+^ sustain. Stimulatio