A study of nephrotoxin-induced acute tubular necrosis with 31P magnetic resonance spectroscopy

✍ Scribed by Thomas Schutz; Ricardo González-Méndez; Donald C. Nabseth; Bruce M. Tune; Oleg Jardetzky; David K. Stevenson

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 648 KB
• Volume: 18
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910180116

✦ Synopsis

Abstract

Phosphorus magnetic resonance spectroscopy (^31^P MRS) was used to obtain in vivo spectra from rat kidneys undergoing acute tubular necrosis induced by a nephrotoxic dose of cephaloridine (CLD). Spectra were obtained 0, 24, and 48 h after injection of CLD (experimental group, n = 6) or saline vehicle (control group, n = 6). The nephrotoxicity of CLD was demonstrated by severely increased serum creatinine levels and the development of extensive proximal tubular necrosis in the CLD‐injected rats, and the lack of such changes in the controls. ^31^P MRS showed an increase in the inorganic phosphate region signal (P~1~, p = 0.004) and a decrease in the phosphodiester region signal (PDE, p = 0.01) in the experimental group by 48 h, whereas these parameters did not vary significantly in the control group during the experiment. Significant correlations were found between serum creatinine and the same two ^31^P MRS parameters. In summary, rat kidneys which have developed severe CLDinduced proximal tubular necrosis exhibit changes in the ^31^P spectrum 48 h after administration of the drug. The causes of these changes were not determined. © 1991 Academic Press. Inc.