## HERPES SIMPLEX TYPE-2 ANTIBODY IN SERA OF SUBJECTS WHO Paired sera taken from 63 subjects who developed cervical neoplasia in the course of a prospective study on this disease were examined for the presence of herpes simplex virus type 2 (HSV-2) antibody. The first serum was taken at enrolment
A study of herpes simplex type 2 antibody status in groups of patients with cervical neoplasia in Czechoslovakia
β Scribed by Z. Janda; J. Kanka; V. Vonka; B. Svoboda
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 366 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
Abstract
Sera collected from patients with cervical epithelial atypia, carcinoma in situ and invasive carcinoma, as well as from control subjects, were examined for the presence of HSVβ1 and HSVβ2 antibodies. All these subjects came from one district of Prague. In agreement with results reported from other laboratories, the serological findings indicated that the prevalence of HSV type 2 antibodies was markedly higher in the groups of patients with different stages of neoplastic process in the cervix, than in control groups of comparable age and socioeconomic status. The geometric mean titres for both HSV type 1 and type 2 antibodies were higher in the invasive carcinoma patient group than in other groups of patients.
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To estimate the risk of developing cervical intra-epithelial neoplasia (CIN) among women exposed to human papillomavirus (HPV) type 16, we performed a prospective study in a population-based cohort of more than 15, OOO women followed for 34.9 months. Seventy-four women developed CIN during follow-up