A study of genetic association between manic-depressive illness and a highly polymorphic marker from the GABRβ-1 gene

✍ Scribed by Puertollano, Rosa; Visedo, Gillermo; Zapata, Carlos; Fernández-Piqueras, José

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 208 KB
• Volume: 74
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19970531)74:3<342::aid-ajmg18>3.0.co;2-o

✦ Synopsis

We report on an association study between a tetranucleotide repeat polymorphism in the GABR␤1 gene and manic-depressive illness in a Spanish population. This gene may be an important candidate for bipolar affective disorders since severe GABergic alterations have been described in patients. Although our results do not reveal a clear evidence for association between manic-depressive illness and GABR␤1, we have found significant differences between patients and controls in the female subpopulation. Am. J. Med. Genet. 74:342-344, 1997.