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A Structure−Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers

✍ Scribed by Roufos, Ioannis; Hays, Sheryl; Schwarz, Roy D.


Book ID
125498149
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
323 KB
Volume
39
Category
Article
ISSN
0022-2623

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Structure-activity relationship of Ca2+c
✍ L. Belvisi; S. Brossa; A. Salimbeni; C. Scolastico; R. Todeschini 📂 Article 📅 1991 🏛 Springer Netherlands 🌐 English ⚖ 753 KB

A structure-activity relationship study has been done on 8 compounds with the activity known as 'Ca2+ channel blockers'. Conformational analysis was carried out using a molecular mechanics method. The 3D-QSAR approach was used and the most polar functional groups present in all the molecules were co