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A structurally simple minimal self-replicating system

✍ Scribed by Julie M Quayle; Alexandra M.Z Slawin; Douglas Philp


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
138 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


Molecular recognition between an amidopyridine and a carboxylic acid through two complementary hydrogen bonding sites renders the reaction between an azide and a maleimide self-replicating, but not autocatalytic.


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## Abstract It is commonly agreed that a chemical assembly of molecules can be considered alive if it can ingest resources and convert them into building blocks; has the ability to grow and self‐reproduce; and can evolve. In the design proposed by Rasmussen and Chen (Science 2004, 303, 963) the ass