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A structural somatic variant of the Kkantigen is generated by point mutation

✍ Scribed by Günther Karmann; Konrad T. Beyreuther; Matthias Cramer; Bodo Holtkamp; Susanne Proksa; Klaus Rajewsky

Publisher: Springer-Verlag
Year: 1985
Tongue: English
Weight: 810 KB
Volume: 22
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00430592

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✦ Synopsis

We have previously selected structural variants of the K k antigen from a (C3 x D2)F~ T-cell lymphoma. Those mutants were identified by the loss of certain epitopes defined by monoclonal antibodies. The variant K k molecule from HK 13.$3 cells is no longer recognized by 40% of the trinitrophenyl-specific, Kk-restricted cytotoxic T lymphocytes. Here we report on the primary structure of the altered K k molecules from the cell line HK13.S3. Comparison with the parental K k reveals a single base pair exchange, GCG to GTG, that results in an alanine to valine exchange in position 40 of the protein. This observation emphasizes that minor structural alterations in class I molecules may have a strong effect on the H-2-restricted T-cell response.

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