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A Structural Model for the Galactose Oxidase Active Site which Shows Counteranion-Dependent Phenoxyl Radical Formation by Disproportionation

โœ Scribed by Yuichi Shimazaki; Stefan Huth; Akira Odani; Osamu Yamauchi


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
128 KB
Volume
39
Category
Article
ISSN
0044-8249

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A Structural Model for the Galactose Oxi
โœ Yuichi Shimazaki; Stefan Huth; Akira Odani; Osamu Yamauchi ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 124 KB

Galactose oxidase (GO) contains one copper ion at its active site and performs a two-electron oxidation of primary alcohols to aldehydes, coupled with a reduction of O 2 to eomer in 68 % yield. The entire sequence was performed in 24 linear steps from (S)-malic acid. The material thus obtained was s