A structural model for monastrol inhibition of dimeric kinesin Eg5
β Scribed by Krzysiak, Troy C; Wendt, Thomas; Sproul, Lisa R; Tittmann, Peter; Gross, Heinz; Gilbert, Susan P; Hoenger, Andreas
- Book ID
- 110031495
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 751 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0261-4189
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π SIMILAR VOLUMES
The conformational features of the mitotic kinesin Eg5 inhibitor monastrol were investigated by computational (AM1, HF/3-21G β«Ψ‘β¬ ), X-ray diffraction, and NMR studies showing that monastrol is a conformationally highly flexible molecule. Racemic monastrol was resolved by direct enantioselective HPLC
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