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A Structural and Dynamics Survey of HIV-1 Reverse Transcriptase

โœ Scribed by Seckler, James M.; Miao, Hongyu; Grossfield, Alan M.


Book ID
122838287
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
35 KB
Volume
104
Category
Article
ISSN
0006-3495

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Major subdomain rearrangement in HIV-1 r
โœ M. Madrid; A. Jacobo-Molina; J. Ding; E. Arnold ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 132 KB

We have performed eight 1-ns in vacuo molecular dynamics simulations of HIV-1 reverse transcriptase (RT). Starting with the p66 thumb subdomain in an upright configuration, the p66 thumb moved down over the palm during six of the eight trajectories, in excellent agreement with the crystallographic s