A strategy to avoid anomalous O-alkylati
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George Papageorgiou; John E. T. Corrie
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Article
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2005
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Journal of Heterocyclic Chemistry
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English
β 69 KB
Alkylation of 4-hydroxyindole with diethyl bromomalonate under standard conditions (potassium carbonate-acetone) gave the expected indolyloxymalonate ester 3 together with the anomalous indolyloxy-2-bromomalonate 4. Depending on conditions, the ratio of the two products varied between 4:1 and 1:2. P