A straightforward synthesis of pentosidine framework
β Scribed by Yahua Liu; Weihan Zhang; Lawrence M. Sayre
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 279 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.374
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
magnified image
Pentosidine framework 4βbutylβ2βpropylβ4__H__βaminoimidazo[4,5βb]pyridine (2) was synthesized through a five steps reaction sequence. The regiochemistry of 2 was confirmed by an unambiguous synthesis, and the UV absorption and fluorescent properties of 2 were examined. J. Heterocyclic Chem., (2010).
π SIMILAR VOLUMES
## Abstract Pentosidine, a fluorescent advanced glycation endproduct that serves as a biomarker of diabetic complications, kidney dysfunction, oxidative stress, and aging and ageβrelated diseases, was synthesized from 2,3βdiaminopyridine and benzyloxycarbonyl (Cbz) protected chiral amino acids __N_